SEMA7A抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P12150(SEMA7A Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

SEMA7A (semaphorin 7A) is a glycosylphosphatidylinositol (GPI)-anchored membrane protein belonging to the semaphorin family, known for its dual roles in immune regulation and neural development. It interacts with receptors such as integrins (e.g., β1-integrin) and plexin C1. mediating cell-cell signaling involved in immune responses, axon guidance, and tissue remodeling. SEMA7A is expressed in various cell types, including lymphocytes, neurons, and epithelial cells, and plays critical roles in processes like T-cell activation, macrophage migration, and neuronal outgrowth. Dysregulation of SEMA7A has been implicated in pathologies such as cancer metastasis, inflammatory diseases (e.g., rheumatoid arthritis), and neurodegenerative disorders.

Antibodies targeting SEMA7A are essential tools for studying its expression, localization, and function. They are used in applications like Western blotting, immunohistochemistry, flow cytometry, and functional blocking experiments. Monoclonal antibodies offer high specificity, while polyclonal antibodies may detect multiple epitopes. Research using SEMA7A antibodies has revealed its involvement in tumor microenvironment modulation, immune cell trafficking, and neural repair mechanisms. Therapeutic potential is also being explored, with antibodies investigated for blocking SEMA7A-mediated pathways in autoimmune diseases or enhancing tissue regeneration. However, challenges remain in understanding isoform-specific functions and optimizing antibody specificity for clinical translation.