SEC14L2抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse liver tissue, PC3 cells, human fetal liver tissue, Primary antibody: P12144(SEC14L2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12144(SEC14L2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12144(SEC14L2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The SEC14L2 antibody is a tool used to detect the SEC14-like protein 2 (SEC14L2), a member of the SEC14 domain-containing protein family. SEC14L2 is implicated in lipid metabolism and intracellular trafficking, sharing structural homology with yeast Sec14p, a phosphatidylinositol transfer protein critical for membrane dynamics. In mammals, SEC14L2 is thought to regulate vesicle transport, lipid signaling, and membrane interactions, though its precise mechanisms remain under investigation. It is expressed in various tissues, including the liver, kidney, and gastrointestinal tract, suggesting roles in organ-specific lipid homeostasis.

Antibodies targeting SEC14L2 are primarily utilized in research to study its expression, localization, and function in cellular and disease contexts. For instance, SEC14L2 has been linked to cancer progression, with studies indicating altered expression in tumors, potentially influencing cell proliferation and metastasis. Additionally, SEC14L2 may interact with vitamin E-binding proteins, hinting at its involvement in antioxidant pathways. Researchers employ SEC14L2 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore these associations. The development of specific, high-affinity antibodies has been crucial for distinguishing SEC14L2 from homologous family members, enabling precise functional studies. Ongoing research aims to clarify its therapeutic potential, particularly in metabolic disorders and cancers, positioning SEC14L2 as a biomarker or target for intervention.