IQCJ抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12137(IQCJ Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P12137(IQCJ Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The IQCJ antibody is a research tool targeting the IQ motif-containing protein J (IQCJ), also known as CFAP46. a member of the IQ motif protein family. These proteins are characterized by calcium-binding IQ domains that mediate interactions with calmodulin and other signaling molecules. IQCJ is primarily expressed in ciliated tissues, including the brain, testis, and respiratory epithelium, and is implicated in ciliary structure and function. Studies suggest its role in regulating ciliary motility and intracellular signaling pathways, particularly in neuronal and reproductive systems.

IQCJ antibodies are widely used in basic research to investigate ciliopathies, neurodevelopmental disorders, and infertility linked to ciliary dysfunction. They enable detection of IQCJ expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in localization studies and protein interaction analyses. Recent work has explored IQCJ's association with primary ciliary dyskinesia (PCD) and its potential as a biomarker for ciliary-related pathologies.

Despite its emerging significance, IQCJ's precise molecular mechanisms remain understudied. Current antibody development focuses on improving specificity to address cross-reactivity with homologous IQ domain proteins. These antibodies are critical for advancing understanding of cilia biology and developing therapeutic strategies for diseases tied to ciliary defects.