SAMD9抗体

The SAMD9 antibody targets the SAM domain-containing protein 9 (SAMD9), a gene located on chromosome 7 (7q21.2) that encodes a protein involved in innate immunity, cell proliferation regulation, and inflammatory responses. SAMD9 is characterized by its sterile alpha motif (SAM) domain, which mediates protein-protein interactions. It acts as a tumor suppressor and plays roles in antiviral defense, particularly by restricting viral replication through endolysosomal trafficking modulation. Dysregulation or mutations in SAMD9 are linked to human diseases, including myelodysplastic syndromes (e.g., familial monosomy 7 syndrome), ataxia-pancytopenia syndrome, and certain neurodevelopmental disorders. SAMD9 antibodies are primarily used in research to detect protein expression levels, subcellular localization (e.g., cytoplasmic or endosomal), and functional studies. They aid in understanding SAMD9's role in pathological contexts, such as its gain-of-function mutations causing cellular stress and bone marrow failure. Commercially available SAMD9 antibodies include monoclonal and polyclonal variants, validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore SAMD9's interaction with viral proteins and its potential as a biomarker or therapeutic target. However, antibody specificity and cross-reactivity with SAMD9L (a paralog) require careful validation in experimental setups.