RORB抗体

+ +

•  

   

     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: P12117(RORB Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12117(RORB Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12117(RORB Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

RORB (Retinoic Acid Receptor-Related Orphan Receptor Beta) is a nuclear receptor and transcription factor encoded by the RORB gene, playing critical roles in developmental processes, circadian rhythm regulation, and neuronal differentiation. As a member of the ROR subfamily, it binds to specific DNA response elements to modulate gene expression, often interacting with co-activators or repressors. RORB is highly expressed in the brain, particularly in the cortex, thalamus, and retina, where it influences neuronal subtype specification and circuit formation. It also regulates photoreceptor cell development in the retina.

RORB antibodies are essential tools in neuroscience research, used to detect and localize RORB protein in tissues or cells via techniques like immunohistochemistry (IHC), Western blotting, or immunofluorescence (IF). These antibodies help investigate RORB's role in neurodevelopmental disorders (e.g., autism spectrum disorders), circadian dysfunction, and retinal diseases. Studies link RORB mutations or dysregulation to pathological conditions, including epilepsy and bipolar disorder. Researchers also utilize RORB antibodies to identify specific neuronal populations in brain mapping projects. Available as monoclonal or polyclonal variants, their specificity is validated through knockout controls or siRNA-based approaches. Optimal performance depends on experimental conditions, emphasizing the need for protocol optimization.