RAD54B抗体

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12094(RAD54B Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12094(RAD54B Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

RAD54B antibody is a specialized tool used to detect and study the RAD54B protein, a key player in DNA repair and homologous recombination. Belonging to the RAD54 family of DNA-dependent ATPases, RAD54B facilitates genomic stability by working alongside RAD51 to repair double-strand breaks (DSBs) through the homologous recombination repair (HRR) pathway. This protein enhances RAD51’s ability to form nucleoprotein filaments on single-stranded DNA, promoting strand pairing and exchange—a critical step in error-free DNA repair. Dysregulation of RAD54B is linked to genomic instability, carcinogenesis, and chemotherapy resistance, making it a focus in cancer research, particularly in BRCA-mutant cancers with defective HRR.

The RAD54B antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, localization, and interactions in various tissues and cancer models. Studies leveraging this antibody have revealed RAD54B’s roles in meiosis, somatic cell proliferation, and tumor suppression. Its expression is often downregulated in cancers such as colorectal and breast carcinomas, correlating with poor prognosis. Additionally, RAD54B antibodies aid in exploring synthetic lethality strategies, where inhibiting alternative repair pathways in HRR-deficient cells could enhance therapeutic outcomes. Researchers also investigate its potential as a biomarker for predicting treatment responses in DNA-damaging therapies. Overall, RAD54B antibodies are vital for advancing our understanding of DNA repair mechanisms and developing targeted cancer therapies.