RAB24抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12092(RAB24 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12092(RAB24 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

RAB24 antibodies are immunological tools used to detect and study RAB24. a member of the RAS-associated binding (RAB) GTPase family involved in intracellular vesicular trafficking and autophagy regulation. RAB24. a small GTP-binding protein, shares structural homology with other RAB proteins but exhibits unique functional characteristics. It localizes to autophagosomes, lysosomes, and the endoplasmic reticulum, playing roles in autophagosome maturation, lysosomal degradation, and cellular stress responses. Dysregulation of RAB24 has been implicated in neurodegenerative diseases, cancer, and immune disorders, making it a target for mechanistic studies.

RAB24 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable researchers to investigate RAB24 expression, subcellular localization, and interactions via techniques such as Western blotting, immunofluorescence, and immunoprecipitation. Commercial antibodies often vary in specificity and applications depending on epitope regions and clonal types (monoclonal/polyclonal). Validation includes testing in knockout cell lines or tissues to confirm target specificity. Researchers utilize these antibodies to explore RAB24's involvement in autophagy-lysosomal pathways, membrane trafficking dynamics, and disease mechanisms, particularly in contexts like tumor progression or protein aggregation disorders. Proper controls are critical due to potential cross-reactivity with other RAB family members.