PTPN4抗体

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P12084(PTPN4 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P12084(PTPN4 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The PTPN4 antibody targets the protein tyrosine phosphatase non-receptor type 4 (PTPN4), a member of the protein tyrosine phosphatase (PTP) family. PTPN4. also known as PTPMEG, is encoded by the PTPN4 gene and plays a critical role in regulating cellular signaling by dephosphorylating tyrosine residues on target proteins. It contains an N-terminal FERM domain, which mediates protein-protein interactions and subcellular localization, and a C-terminal catalytic domain responsible for phosphatase activity. PTPN4 is involved in diverse physiological processes, including immune response modulation, neuronal development, and apoptosis. Studies suggest its role in negative regulation of T-cell receptor signaling and prevention of autoimmunity. Dysregulation of PTPN4 has been implicated in neurological disorders and cancer, where it may act as a tumor suppressor or promoter depending on context.

PTPN4 antibodies are essential tools for studying the expression, localization, and function of this phosphatase in research. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cell lines. Commercially available antibodies vary in specificity, often validated against recombinant PTPN4 or epitope-tagged versions. Researchers utilize these antibodies to explore PTPN4's interactions with signaling molecules (e.g., JNK, MAPK) and its potential as a therapeutic target. However, challenges remain in distinguishing PTPN4 from homologous phosphatases, necessitating rigorous validation. Recent investigations also focus on PTPN4's role in viral immune evasion, highlighting its broader relevance in infection biology.