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PTPN20抗体

Rabbit Polyclonal PTPN20 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-15

湖北瑞和宁生物科技有限公司

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邮箱：19384116026@163.com

产品详情:

中文名称：
PTPN20抗体
英文名称：
Rabbit Polyclonal PTPN20 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 6437 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
PTPN20

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCT126; PTPN20A; PTPN20B; bA42B19.1; bA142I17.1
WB Predicted band size48 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human PTPN20
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 cells, human testis tissue, Primary antibody: P12083(PTPN20 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P12083(PTPN20 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P12083(PTPN20 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于PTPN20抗体的参考文献示例(内容为模拟，建议通过学术数据库核实最新文献)：

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1. **标题**: *PTPN20 regulates breast cancer cell migration via Src signaling*

**作者**: Lee H, et al.

**摘要**: 本研究利用PTPN20抗体进行免疫印迹和免疫荧光，发现PTPN20通过去磷酸化Src激酶抑制乳腺癌细胞迁移，提示其作为肿瘤抑制因子的潜在作用。

2. **标题**: *PTPN20 modulates T-cell receptor signaling through interaction with LAT*

**作者**: Smith R, et al.

**摘要**: 通过免疫共沉淀(使用PTPN20抗体)，研究揭示了PTPN20与T细胞活化连接蛋白(LAT)的相互作用，调控T细胞受体下游信号通路，影响免疫应答。

3. **标题**: *Loss of PTPN20 promotes oxidative stress resistance in cancer cells*

**作者**: Chen Y, et al.

**摘要**: 使用PTPN20抗体进行组织芯片分析，发现PTPN20缺失通过激活Nrf2通路增强癌细胞抗氧化能力，为其在肿瘤耐药性中的角色提供证据。

4. **标题**: *PTPN20 expression profiling in normal and inflammatory tissues*

**作者**: Gonzalez M, et al.

**摘要**: 通过免疫组化(PTPN20抗体)系统分析了PTPN20在正常组织与炎症模型中的表达差异，提示其可能参与炎症微环境调控。

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**备注**：以上文献为示例性质，实际引用请通过PubMed、Google Scholar等平台以“PTPN20 antibody”或“PTPN20 function”等关键词检索最新研究。

       

背景信息

The PTPN20 antibody targets the protein tyrosine phosphatase non-receptor type 20 (PTPN20), a member of the protein tyrosine phosphatase (PTP) family, which regulates cellular signaling by dephosphorylating tyrosine residues on target proteins. PTPN20. also known as HSCFY1 or LYP9. is a less-characterized phosphatase implicated in modulating cell migration, adhesion, and growth. Structurally, it contains an N-terminal catalytic domain responsible for phosphatase activity and a C-terminal region that may regulate subcellular localization or protein interactions. Studies suggest PTPN20 interacts with receptor tyrosine kinases (RTKs) or adaptor proteins, influencing downstream pathways like MAPK/ERK or Src signaling, though its precise substrates and mechanisms remain under investigation.

PTPN20 expression is tissue-specific, with higher levels observed in hematopoietic cells and certain epithelial tissues. Its dysregulation has been tentatively linked to cancer and inflammatory diseases, though direct evidence is limited. Research using PTPN20 antibodies primarily focuses on detecting endogenous protein expression, subcellular localization (e.g., cytoplasmic or membrane-associated), and functional studies via knockdown or overexpression models. These antibodies are critical tools for elucidating PTPN20's role in physiological processes and pathologies, including its potential as a therapeutic target. Current challenges include clarifying its regulatory networks, substrate specificity, and disease associations to advance translational applications.

       
PTPN20抗体;PTPN20;PTPN20 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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