WDR47抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09962(WDR47 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

**Background of WDR47 Antibody**

The WDR47 (WD Repeat Domain 47) protein, also known as CAKA or KIAA0892. is a member of the WD40-repeat protein family, which plays critical roles in diverse cellular processes, including signal transduction, autophagy, and cytoskeletal organization. Structurally, WDR47 contains seven WD40 repeats that facilitate protein-protein interactions, enabling its involvement in multiprotein complexes. It is particularly noted for its interaction with microtubules and participation in neuronal development, where it regulates axonal outgrowth and guidance by modulating microtubule stability.

WDR47 antibodies are essential tools for studying the protein’s expression, localization, and functional mechanisms. These antibodies are commonly generated in hosts like rabbits or mice using immunogenic peptides derived from conserved regions of human or mouse WDR47. Validated applications include Western blotting, immunofluorescence, and immunoprecipitation, allowing researchers to investigate WDR47’s role in neurodevelopmental disorders, cancer, and neurodegenerative diseases. For instance, studies link WDR47 dysregulation to glioblastoma progression and intellectual disability.

High-quality WDR47 antibodies undergo rigorous validation for specificity (e.g., knockout cell controls) and reproducibility. Commercial antibodies often provide datasheets detailing their reactivity across species (human, mouse, rat) and recommended experimental conditions. Researchers prioritize these reagents to explore WDR47’s interplay with pathways like the PI3K/AKT/mTOR axis or its association with autophagy-related proteins, advancing insights into cellular homeostasis and disease mechanisms.