TEX11抗体

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09961(TEX11 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09961(TEX11 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The TEX11 antibody is a valuable tool in reproductive biology and cancer research, targeting the TEX11 protein encoded by the *TEX11* gene located on the X chromosome. TEX11 is predominantly expressed in germ cells, where it plays a critical role in meiotic recombination, synapsis, and chromosomal stability during spermatogenesis. Studies have linked *TEX11* mutations to male infertility, particularly non-obstructive azoospermia, due to its essential function in meiosis. In females, TEX11 contributes to oocyte development, though its roles are less characterized.

The TEX11 antibody is widely used to detect and quantify TEX11 protein expression in tissues and cell lines, employing techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity enables researchers to explore TEX11's spatial and temporal expression patterns during gametogenesis, aiding in mechanistic studies of infertility. Beyond reproductive health, TEX11 has emerged in oncology due to its aberrant expression in certain cancers, including germ cell tumors and some somatic malignancies, suggesting potential roles in tumorigenesis or therapy resistance.

Commercial TEX11 antibodies are typically raised in rabbits or mice, with validation in knockout models to confirm specificity. As a research reagent, it bridges basic science and clinical applications, offering insights into both developmental disorders and cancer biology. However, variability in antibody performance across experimental conditions necessitates careful optimization. Overall, the TEX11 antibody remains pivotal in advancing our understanding of reproductive health and disease.