TTC16抗体

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 231 cell lysate, Primary antibody: P09955(TTC16 Antibody) at dilution 1/1150, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

The TTC16 antibody is a research tool designed to target the TTC16 protein, a member of the tetratricopeptide repeat (TPR) domain-containing protein family. TTC16. encoded by the *TTC16* gene, is implicated in cellular processes such as ciliogenesis, intracellular trafficking, and protein-protein interactions. Its TPR motifs facilitate binding to partner proteins, potentially regulating molecular chaperone activities or signaling pathways.

Interest in TTC16 stems from its association with cilia-related functions and diseases. Studies link TTC16 dysfunction to male infertility, ciliopathies, and developmental disorders, highlighting its role in ciliary assembly/maintenance. The antibody enables detection and localization of TTC16 in tissues/cells, aiding investigations into its physiological and pathological mechanisms.

Commercially available TTC16 antibodies are typically developed in rabbits or mice using recombinant protein fragments or synthetic peptides. They are validated for applications like Western blotting, immunofluorescence, and immunohistochemistry. However, specificity and batch variability require careful optimization, as cross-reactivity with other TPR-containing proteins remains a concern.

Current research employs TTC16 antibodies to explore its interactions with ciliary components (e.g., IFT complexes) and its potential as a biomarker. Ongoing studies aim to clarify its precise molecular roles, offering insights into cilia-related diseases and therapeutic targets.