FSCB抗体

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09953(FSCB Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09953(FSCB Antibody) at dilution 1/100. (Original magnification: ×200)    

  
  

Fibrous Sheath CABinding protein (FSCB) is a sperm-specific protein predominantly localized in the fibrous sheath, a cytoskeletal structure surrounding the axoneme in the principal piece of mammalian sperm tails. It plays a critical role in sperm motility and maturation. FSCB was first identified through proteomic studies targeting sperm components involved in fertilization and male infertility. The protein contains multiple phosphorylation sites and a calcium-binding domain, suggesting its involvement in calcium-dependent signaling pathways during sperm capacitation and the acrosome reaction.

FSCB antibodies are primarily used in reproductive biology research to investigate sperm function, structural integrity, and molecular mechanisms underlying infertility. These antibodies enable the detection and localization of FSCB in spermatozoa via techniques like immunofluorescence, Western blotting, and immunohistochemistry. Studies have shown that abnormal expression or mutations in FSCB correlate with impaired sperm motility and structural defects, making it a potential biomarker for diagnosing certain forms of male infertility.

Commercial FSCB antibodies are typically raised against specific epitopes, such as recombinant fragments or synthetic peptides corresponding to conserved regions of the protein. Their application extends to comparative studies across species, given FSCB's evolutionary conservation in mammals. Ongoing research explores FSCB's interactions with other fibrous sheath proteins (e.g., CABYR) and its role in energy regulation within sperm, highlighting its significance in both basic reproductive science and clinical diagnostics.