TTC14抗体

The TTC14 antibody is a research tool designed to target the TTC14 protein, a member of the tetratricopeptide repeat (TPR) domain-containing protein family. TTC14. encoded by the TTC14 gene in humans, is a relatively understudied protein implicated in cellular processes such as cilia function, cell cycle regulation, and protein-protein interactions. Its TPR motifs suggest a role in scaffolding or mediating molecular assemblies, though its exact biological mechanisms remain unclear. The antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect TTC14 expression and localization in various tissues and cell types. Studies have linked TTC14 to ciliopathies and developmental disorders, given its potential involvement in ciliary signaling pathways. However, research on TTC14 remains limited, and the antibody serves primarily as an exploratory reagent to elucidate its physiological and pathological roles. Commercial TTC14 antibodies are typically validated for specificity using knockout controls or siRNA-mediated protein knockdown. Researchers utilize this tool to investigate TTC14's interaction networks, tissue distribution, and potential associations with diseases like renal dysfunction or neurological conditions. Ongoing work aims to clarify whether TTC14 mutations or dysregulation contribute to human pathologies, emphasizing the antibody's importance in foundational studies.