CFAP47抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09947(CFAP47 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

The CFAP47 antibody is designed to target the Cilia and Flagella Associated Protein 47 (CFAP47), a protein implicated in the structure and function of motile cilia and flagella. CFAP47 is part of a conserved protein family involved in ciliary motility, which plays critical roles in cellular movement, fluid propulsion, and sensory signaling. Mutations in CFAP47 or related genes have been linked to ciliopathies, such as primary ciliary dyskinesia (PCD), a genetic disorder characterized by impaired mucociliary clearance, recurrent respiratory infections, and infertility due to defective sperm flagella or ciliary dysfunction in fallopian tubes.

Research on CFAP47 has focused on its localization within the axoneme—the microtubule-based core of cilia and flagella—and its interaction with other dynein-associated proteins to regulate ciliary beating. The CFAP47 antibody is a vital tool for studying these mechanisms, enabling detection and visualization of the protein via techniques like immunofluorescence, Western blotting, or immunohistochemistry. It has been utilized in both clinical and basic research settings to explore CFAP47 expression patterns in tissues such as respiratory epithelia, sperm cells, and model organisms (e.g., mice, zebrafish). Studies using this antibody contribute to understanding ciliary biology, disease pathogenesis, and potential therapeutic strategies for ciliopathies.