PHTF1抗体

The PHTF1 (PH Domain-Containing Transcription Factor 1) antibody is a tool used to study the PHTF1 protein, encoded by the *PHTF1* gene in humans. PHTF1 contains a pleckstrin homology (PH) domain, a structural motif often involved in membrane association or protein-protein interactions. While its precise biological role remains under investigation, PHTF1 is implicated in cellular processes such as transcriptional regulation, cell cycle control, and apoptosis. Studies suggest it may act as a tumor suppressor or oncogene depending on context, with altered expression observed in cancers like hepatocellular carcinoma and glioblastoma. The antibody enables detection and localization of PHTF1 in tissues or cultured cells via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Research using this reagent has explored PHTF1's nuclear-cytoplasmic shuttling behavior, potential DNA-binding capacity, and interactions with signaling pathways like PI3K/AKT. Its development has facilitated investigations into PHTF1's role in tumorigenesis, therapeutic resistance, and cellular stress responses, though further functional characterization is needed to fully define its molecular mechanisms and clinical relevance.