PPM1G抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09927(PPM1G Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09927(PPM1G Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The PPM1G antibody is a key tool for studying the protein phosphatase, Mg²+/Mn²+-dependent 1G (PPM1G), also known as PP2Cγ. PPM1G belongs to the PP2C family of serine/threonine phosphatases, which regulate diverse cellular processes by dephosphorylating target proteins. This enzyme is involved in critical pathways, including RNA splicing, DNA damage response, and cell cycle progression. It interacts with components of the spliceosome (e.g., SAP155) and modulates pre-mRNA processing, as well as dephosphorylates ATM/ATR substrates to influence genomic stability. Dysregulation of PPM1G has been linked to cancers, neurodegenerative disorders, and metabolic diseases, highlighting its therapeutic relevance.

PPM1G antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect protein expression, localization, and interactions. Researchers rely on these antibodies to investigate PPM1G’s role in cellular stress responses, its regulation of splicing machinery, and its impact on transcriptional programs. Specificity is ensured through validation in knockout models or siRNA-mediated knockdowns. Both polyclonal and monoclonal variants are available, with applications spanning basic research and drug development. By enabling precise analysis of PPM1G’s functions, these antibodies contribute to understanding its dual roles as a tumor suppressor or promoter, depending on cellular context.