PWP1抗体

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09922(PWP1 Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

The PWP1 antibody is a research tool designed to detect and study the Periodic Tryptophan Protein 1 (PWP1), a conserved eukaryotic protein belonging to the WD40-repeat family. PWP1 plays a critical role in ribosome biogenesis, particularly in rRNA processing and the assembly of ribosomal subunits. It is part of the UTP (U Three Protein) complex involved in the early stages of 18S rRNA maturation, linking its function to cellular growth, proliferation, and homeostasis. Dysregulation of PWP1 has been implicated in developmental disorders and diseases like cancer, making it a subject of interest in molecular biology and translational research.

The antibody is commonly used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate PWP1 expression, localization, and interactions. Its specificity is validated using knockout controls or siRNA-mediated depletion. Studies employing PWP1 antibodies have shed light on its nucleolar localization, dynamic behavior during the cell cycle, and involvement in ribosome assembly pathways across model organisms, including yeast and mammals. Researchers also utilize it to explore PWP1's role in stress responses, metabolic pathways, and potential crosstalk with oncogenic signaling. As ribosome dysfunction gains attention in disease mechanisms, PWP1 antibodies remain vital for dissecting its biological and pathological relevance.