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PSMD12抗体

Rabbit Polyclonal PSMD12 Antibody

询价 20μl 起订

50μl 起订

100μl 起订

湖北更新日期：2025-05-14

湖北瑞和宁生物科技有限公司

非会员

联系人：周***

电话：027***

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邮箱：193***

产品详情:

中文名称：: PSMD12抗体

英文名称：: Rabbit Polyclonal PSMD12 Antibody

品牌：: 艾普蒂

产地：: 武汉

保存条件：: Stored at -20°C for 5141 year. Avoid repeated freeze / thaw cycles.

产品类别：: 抗体

重组：: 否

应用：: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA

种属反应性：: Human,Mouse,Rat

宿主：: Rabbit

偶联物：: 无

靶点：: PSMD12

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	1/40-1/200	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	1/5000-1/10000	Human,Mouse,Rat

产品详情

Aliases	p55; Rpn5; STISS
WB Predicted band size	53 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Fusion protein of human PSMD12
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Rat heart tissue lysate, Primary antibody: P09918(PSMD12 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09918(PSMD12 Antibody) at dilution 1/40. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09918(PSMD12 Antibody) at dilution 1/40. (Original magnification: ×200)

参考文献

以下是3篇关于PSMD12抗体的参考文献概览(虚构示例，供参考)：

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1. **文献名称**: *PSMD12 regulates proteasome activity and cancer cell survival via deubiquitination*

**作者**: Chen L, et al.

**摘要**: 本研究利用PSMD12特异性抗体进行免疫沉淀和Western blot分析，发现PSMD12通过调控蛋白酶体去泛素化酶活性影响肿瘤细胞凋亡，抗体验证了其在结直肠癌细胞中的高表达。

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2. **文献名称**: *Antibody-based profiling of 26S proteasome subunits in neurodegenerative models*

**作者**: Smith K, et al.

**摘要**: 通过商业化PSMD12抗体的免疫组化实验，揭示阿尔茨海默病模型中蛋白酶体亚基PSMD12的异常聚集，提示其与tau蛋白降解障碍的相关性。

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3. **文献名称**: *CRISPR screening identifies PSMD12 as a critical factor in antiviral immunity*

**作者**: Wang Y, et al.

**摘要**: 结合PSMD12抗体进行功能验证，发现PSMD12敲除显著降低免疫细胞蛋白酶体活性，影响病毒抗原呈递，为抗病毒治疗提供新靶点。

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注：以上为模拟内容，实际文献需通过PubMed等平台检索(可尝试关键词：**PSMD12 antibody proteasome**)。

背景信息

The PSMD12 antibody is a research tool targeting the PSMD12 protein, a key component of the 26S proteasome. PSMD12 (Proteasome 26S Subunit, Non-ATPase 12), also known as RPN5. is part of the 19S regulatory particle within the ubiquitin-proteasome system (UPS). This system governs intracellular protein degradation, critical for regulating cell cycle progression, apoptosis, and signal transduction. PSMD12 functions as a non-ATPase subunit in the 19S base, assisting in substrate recognition, deubiquitination, and translocation of ubiquitinated proteins into the proteolytic 20S core. Dysregulation of PSMD12 has been implicated in cancer, neurodegenerative disorders, and autoimmune diseases due to its role in maintaining protein homeostasis.

PSMD12 antibodies are widely used in Western blotting, immunohistochemistry, and immunoprecipitation to study protein expression, localization, and interactions. They help elucidate PSMD12's involvement in disease mechanisms, such as tumorigenesis linked to proteasome overactivity or neurodegeneration caused by impaired protein clearance. Recent studies also explore PSMD12 as a potential therapeutic target, with inhibitors under investigation for cancer treatment. When selecting a PSMD12 antibody, researchers prioritize specificity validated via knockout controls, cross-reactivity across species (e.g., human, mouse), and compatibility with intended applications. Commercial antibodies are typically developed in rabbit or mouse hosts, with monoclonal and polyclonal options available for diverse experimental needs.

PSMD12抗体;PSMD12;PSMD12 Antibody;

公司简介

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成立日期	(2年)
注册资本	50万(元)
员工人数	1-10人
年营业额	￥ 100万以内
经营模式	贸易,工厂,试剂,定制,服务
主营行业	中间体,化学试剂