RMND5A抗体

The RMND5A antibody is a research tool designed to detect and study the RMND5A protein, a member of the RING finger protein family implicated in ubiquitination and cellular regulation. RMND5A (Required for Meiotic Nuclear Division 5 Homolog A) is an E3 ubiquitin ligase involved in substrate-specific protein degradation via the ubiquitin-proteasome system. It plays roles in mitochondrial function, cell cycle regulation, and DNA damage response, with emerging links to diseases such as cancer and neurodegenerative disorders. The antibody is commonly raised in hosts like rabbits or mice using immunogenic peptide sequences unique to RMND5A. It enables detection of endogenous protein expression through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies highlight its utility in exploring RMND5A's interaction networks, subcellular localization (particularly mitochondrial associations), and dysregulation in pathologies. Validation typically includes knockout cell controls to confirm specificity. As research expands, this antibody remains critical for deciphering RMND5A's molecular mechanisms and therapeutic potential.