KRR1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human heart tissue lysate , Primary antibody: P09901(KRR1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 7 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09901(KRR1 Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

**Background of KRR1 Antibody**

KRR1 (KRI1 homolog, ribosome maturation factor) is a conserved eukaryotic protein involved in ribosomal RNA (rRNA) processing and ribosome biogenesis. It plays a critical role in the maturation of 18S rRNA, a core component of the small ribosomal subunit, by interacting with other ribosome assembly factors. Dysregulation of KRR1 has been linked to cellular stress responses, cell cycle progression, and pathologies such as cancer, where aberrant ribosome biogenesis is a hallmark.

KRR1 antibodies are immunological tools designed to detect and quantify KRR1 protein levels in various experimental settings, including Western blotting, immunofluorescence, and immunohistochemistry. These antibodies are essential for studying KRR1's expression patterns, subcellular localization (primarily nucleolar), and interactions within ribosome assembly pathways. They also help explore its functional roles in development, disease mechanisms, and potential therapeutic targeting.

Research using KRR1 antibodies has revealed its involvement in maintaining genomic stability and regulating cell proliferation, making it a biomarker of interest in oncology. Additionally, studies in model organisms, such as yeast and mice, highlight its evolutionary conservation and fundamental role in ribosome homeostasis. Validated KRR1 antibodies are crucial for advancing understanding of ribosomopathies and cancers driven by defective ribosomal synthesis.