TXNL1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: PC3 cell, HepG2 cell lysates, Primary antibody: P09891(TXNL1 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09891(TXNL1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09891(TXNL1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The TXNL1 antibody is a research tool designed to detect thioredoxin-like protein 1 (TXNL1), a member of the thioredoxin family involved in redox regulation. TXNL1. also known as TRP32 or TXNDC5. contains a conserved thioredoxin domain with a CXXC active site motif, enabling its participation in disulfide bond reduction and cellular antioxidant defense. It plays roles in protein folding, apoptosis regulation, and cellular stress responses, with implications in cancer, neurodegenerative disorders, and oxidative stress-related pathologies.

TXNL1 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant TXNL1 proteins. These antibodies enable the identification and quantification of TXNL1 in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often includes testing specificity via knockout/knockdown controls and assessing cross-reactivity across species (e.g., human, mouse, rat).

Research using TXNL1 antibodies has elucidated its overexpression in certain cancers, where it may promote tumor survival by mitigating oxidative damage, and its downregulation in neurodegenerative conditions linked to protein misfolding. Commercial antibodies vary in clonal type (monoclonal/polyclonal), conjugation (e.g., HRP, fluorescent tags), and applications, requiring careful selection based on experimental needs. Proper controls are essential to ensure accurate interpretation in redox-sensitive studies.