ZNF397抗体

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09887(ZNF397 Antibody) at dilution 1/80. (Original magnification: ×200)    

  
  

The ZNF397 antibody is a crucial tool for studying the zinc finger protein 397 (ZNF397), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (KZFP) family. ZNF397 is implicated in transcriptional regulation and epigenetic modulation, primarily through its interaction with chromatin-modifying complexes. It contains multiple C2H2-type zinc finger domains, which enable sequence-specific DNA binding, and a KRAB domain that recruits co-repressors like heterochromatin protein 1 (HP1) or histone deacetylases (HDACs) to mediate gene silencing. This protein is thought to play roles in cellular processes such as differentiation, apoptosis, and stress response, with emerging links to cancer, neurological disorders, and developmental abnormalities.

The ZNF397 antibody is widely used in research applications, including Western blotting, immunoprecipitation, and immunofluorescence, to detect protein expression, subcellular localization, and interaction partners. Its specificity is critical for distinguishing ZNF397 from other structurally similar zinc finger proteins. Studies utilizing this antibody have explored ZNF397's involvement in tumorigenesis, particularly its dual role as a potential oncogene or tumor suppressor depending on cellular context. Additionally, it aids in investigating ZNF397's regulatory effects on retrotransposons and imprinted genes, contributing to broader understanding of genomic stability and epigenetic inheritance. Validation of the antibody through knockout controls or siRNA knockdown remains essential to ensure reliability in experimental models.