MRPS18B抗体

The MRPS18B antibody is a research tool designed to detect and study the mitochondrial ribosomal protein S18B, a component of the 28S subunit within the mitochondrial ribosome. Mitochondrial ribosomes are essential for synthesizing proteins encoded by mitochondrial DNA, particularly those involved in oxidative phosphorylation and energy production. MRPS18B plays a critical role in maintaining ribosomal stability and facilitating proper assembly during mitochondrial translation. Dysregulation of mitochondrial ribosome proteins, including MRPS18B, has been linked to mitochondrial dysfunction, which is associated with metabolic disorders, neurodegenerative diseases, and cancer. Researchers use MRPS18B antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate its expression patterns, subcellular localization, and interactions with other proteins. These studies help elucidate its role in cellular energy metabolism, apoptosis, and disease mechanisms. Commercially available MRPS18B antibodies are typically validated for specificity using knockdown/knockout controls or peptide-blocking assays. Recent studies also explore its potential as a biomarker in certain cancers, where altered mitochondrial protein synthesis may drive tumor progression. However, functional studies of MRPS18B remain ongoing, and standardized protocols for its detection may vary across experimental models.