MRPL48抗体

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09863(MRPL48 Antibody) at dilution 1/150. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09863(MRPL48 Antibody) at dilution 1/150. (Original magnification: ×200)    

  
  

The MRPL48 antibody is a research tool designed to detect the mitochondrial ribosomal protein L48. a component of the mitochondrial large ribosomal subunit. MRPL48 is part of the mitochondrial ribosome machinery essential for synthesizing proteins encoded by mitochondrial DNA (mtDNA), which are critical for oxidative phosphorylation (OXPHOS) and cellular energy production. This protein plays a role in ribosome assembly, stability, and mitochondrial translation, impacting metabolic homeostasis and mitochondrial function.

Antibodies targeting MRPL48 are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study its expression, localization, and interactions in various tissues or cell lines. Researchers employ these antibodies to investigate mitochondrial disorders, metabolic diseases, and cancers linked to mitochondrial dysfunction, as altered MRPL48 expression may correlate with impaired energy metabolism or disease progression.

Studies utilizing MRPL48 antibodies have contributed to understanding mitochondrial ribosome biogenesis, dynamics, and their implications in aging, neurodegeneration (e.g., Parkinson’s or Alzheimer’s disease), and cancer metabolism. Validated antibodies are crucial for specificity, as cross-reactivity with cytoplasmic ribosomal proteins can occur. Overall, MRPL48 antibodies serve as vital reagents for exploring mitochondrial biology and its connections to human health.