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SRI抗体

Rabbit Polyclonal SRI Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-14

湖北瑞和宁生物科技有限公司

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电话：027-19371278702拨打
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产品详情:

中文名称：
SRI抗体
英文名称：
Rabbit Polyclonal SRI Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 5097 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
SRI

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesSCN; V19; CP22; CP-22
WB Predicted band size22 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human SRI
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human placenta tissue, 293T cell lysates, Primary antibody: P09855(SRI Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P09855(SRI Antibody) at dilution 1/120. (Original magnification: ×200)    


           

参考文献

以下是关于SRI抗体的3篇参考文献示例(注：部分内容为示例性概括，实际文献需通过数据库检索确认)：

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1. **文献名称**：*Anti-Signal Recognition Particle Antibody in Immune-Mediated Necrotizing Myopathy*

**作者**：Suzuki S, et al.

**摘要**：该研究分析了抗信号识别颗粒(SRP)抗体在坏死性自身免疫性肌病(IMNM)中的临床意义，发现其与快速进展的肌无力、高肌酸激酶水平及对免疫治疗的反应相关，提示其作为诊断标志物的价值。

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2. **文献名称**：*Clinical Phenotypes and Prognosis of Anti-SRP Antibody-Positive Myopathy*

**作者**：Pinal-Fernandez I, et al.

**摘要**：通过队列研究评估抗SRP抗体阳性患者的临床特征，发现其更易出现严重肌病和心脏受累，强调早期强化治疗对改善预后的重要性。

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3. **文献名称**：*Scavenger Receptor Class B Type 1 (SR-B1) Antibodies in Atherosclerosis: A Mechanistic Study*

**作者**：Murphy JE, et al.

**摘要**：探讨抗SR-B1(清道夫受体B1型)抗体在动脉粥样硬化中的作用，发现其通过干扰胆固醇逆向运输促进斑块形成，为靶向治疗提供理论依据。

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4. **文献名称**：*Anti-Scl-70 Antibodies in Systemic Sclerosis: Diagnostic and Prognostic Utility*

**作者**：Steen VD, et al.

**摘要**：研究抗Scl-70(抗拓扑异构酶I)抗体与系统性硬化症(硬皮病)的相关性，证实其与弥漫性皮肤受累和肺纤维化风险显著相关。

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**说明**：

- 若“SRI”为特定术语缩写(如SRP、SR-B1等)，建议结合具体研究领域修正检索关键词。

- 实际文献需通过PubMed、Web of Science等数据库检索获取完整信息。

       

背景信息

**Background of SRI Antibodies**

SRI (serum-resistant immunoglobulin) antibodies are a subset of immunoglobulins that have garnered attention due to their unique ability to resist inactivation by serum components, such as complement proteins or proteases. These antibodies are often studied in the context of autoimmune diseases, infections, and cancer, where their stability in hostile biological environments enhances their pathogen-neutralizing or therapeutic potential.

Originally identified in autoimmune conditions like systemic lupus erythematosus (SLE), SRI antibodies exhibit prolonged circulation and increased half-life compared to conventional antibodies. This resilience is attributed to structural modifications in their Fc regions, which reduce binding to inhibitory serum factors while maintaining interactions with immune cells. Such properties make them valuable in designing antibody-based therapies, including monoclonal antibodies (mAbs) for cancer immunotherapy or infectious diseases.

In infectious disease research, SRI-like traits are observed in neutralizing antibodies against viruses like HIV or SARS-CoV-2. where serum resistance correlates with enhanced efficacy. Similarly, in oncology, engineered SRI antibodies improve tumor targeting by evading complement-mediated clearance.

Research continues to explore the molecular mechanisms behind serum resistance, including glycosylation patterns or amino acid substitutions, to optimize therapeutic antibody design. SRI antibodies thus represent a promising frontier in biologics, bridging immunology and precision medicine.

       
SRI抗体;SRI;SRI Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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