TIMM22抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: HEPG2 cell lysate, Primary antibody: P09853(TIMM22 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

The TIMM22 (Translocase of Inner Mitochondrial Membrane 22) antibody is a tool used to study the TIMM22 protein, a key component of the mitochondrial TIM22 complex. TIMM22 plays a critical role in the import and insertion of hydrophobic carrier proteins into the mitochondrial inner membrane. These carrier proteins are essential for metabolic processes, including ATP/ADP exchange, amino acid transport, and ion homeostasis. The TIM22 complex, anchored by TIMM22. facilitates the assembly of these proteins into the membrane, ensuring proper mitochondrial function and energy production.

Antibodies targeting TIMM22 are widely used in research to investigate mitochondrial protein import mechanisms, mitochondrial dysfunction, and associated diseases such as neurodegenerative disorders, metabolic syndromes, and cancer. They enable techniques like Western blotting, immunofluorescence, and immunoprecipitation to assess TIMM22 expression, localization, and interactions. Studies using TIMM22 antibodies have highlighted its role in maintaining mitochondrial membrane potential and its involvement in stress responses.

TIMM22 antibodies are typically validated for specificity across species, including human, mouse, and rat models. Researchers rely on these reagents to explore mitochondrial biology, disease pathways, and therapeutic targets, emphasizing their importance in understanding cellular energy regulation and pathology.