SSC4D抗体

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09849(SSC4D Antibody) at dilution 1/70. (Original magnification: ×200)    

  
  

SSC4D (Sushi domain-containing protein 4) antibodies are immunological tools targeting the SSC4D protein, a member of the sushi domain-containing protein family. SSC4D, also known as SUSD4. is a transmembrane or secreted glycoprotein implicated in cell-cell interactions, immune regulation, and cancer progression. Its structure includes multiple sushi domains, which are conserved motifs involved in protein-protein interactions and complement regulation.

Research suggests SSC4D plays dual roles in physiological and pathological processes. In cancer, SSC4D is overexpressed in certain malignancies (e.g., colorectal, breast) and may promote tumor growth, metastasis, and immune evasion by modulating Wnt/β-catenin signaling or suppressing T-cell activity. Conversely, it exhibits tumor-suppressive effects in other contexts, highlighting tissue-specific functionality. SSC4D antibodies, primarily monoclonal (mAbs), are used to detect protein expression in immunohistochemistry, flow cytometry, and functional studies. Therapeutic applications are being explored, particularly in oncology, where blocking SSC4D may enhance anti-tumor immunity or inhibit pro-metastatic pathways. Challenges include clarifying its conflicting biological roles and optimizing antibody specificity. Current studies focus on its interaction with immune checkpoints (e.g., PD-1/PD-L1 axis) and potential as a companion diagnostic or therapeutic target. Further validation in preclinical models and clinical cohorts is ongoing to establish its translational relevance.