N6AMT1抗体

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09846(N6AMT1 Antibody) at dilution 1/120. (Original magnification: ×200)    

  
  

The N6AMT1 (N-6 adenine-specific DNA methyltransferase 1) antibody is a research tool designed to detect and study the N6AMT1 protein, a methyltransferase enzyme encoded by the *N6AMT1* gene (HGNC:25297). This enzyme is implicated in epigenetic regulation through its potential role in transferring methyl groups to adenine residues in DNA, though its exact substrates and biological functions remain under investigation. N6AMT1 has garnered attention due to its homology to bacterial arsenic methyltransferases, suggesting a possible role in arsenic detoxification. Additionally, aberrant expression of N6AMT1 has been linked to cancer progression, particularly in hepatocellular carcinoma and glioblastoma, where it may influence cell proliferation or drug resistance.

The antibody is widely used in molecular biology and clinical research to localize, quantify, or inhibit N6AMT1 protein expression in tissues or cell lines. It is typically validated for techniques like Western blotting (WB), immunohistochemistry (IHC), or immunoprecipitation (IP). Both monoclonal and polyclonal variants exist, with specificity confirmed via knockout controls. Researchers also employ this antibody to explore N6AMT1’s interaction partners and its role in methylation-dependent pathways. Despite its niche focus, the N6AMT1 antibody contributes to broader studies in epigenetics, toxicology, and oncology, offering insights into disease mechanisms and potential therapeutic targets.