TCAP抗体

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09836(TCAP Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09836(TCAP Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

**Background of TCAP Antibody**

TCAP (telethonin), also known as titin-cap, is a 19-kDa sarcomeric protein predominantly expressed in skeletal and cardiac muscle. It localizes to the Z-disc of sarcomeres, where it interacts with titin, the giant elastic protein responsible for maintaining myofibrillar integrity and mechanosensory signaling. TCAP plays a critical role in stabilizing the Z-disc structure and regulating muscle assembly, elasticity, and stress response.

Mutations in the TCAP gene are linked to limb-girdle muscular dystrophy (LGMD) and hypertrophic or dilated cardiomyopathy, highlighting its importance in muscle health. TCAP antibodies are essential tools for studying these pathologies, enabling detection of TCAP expression levels, cellular localization, and interactions in muscle tissues. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate TCAP's role in myogenesis, disease mechanisms, and potential therapeutic targets.

Research also explores TCAP's involvement in mechanotransduction pathways and its crosstalk with calcium signaling, which influences muscle adaptation to mechanical stress. Additionally, TCAP antibodies aid in diagnosing TCAP-related myopathies and in differentiating them from other muscular dystrophies. Their application extends to preclinical studies evaluating gene therapies or pharmacological interventions aimed at restoring TCAP function in degenerative muscle disorders.