RPL23A抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: 293T cell lysate, Primary antibody: P09832(RPL23A Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09832(RPL23A Antibody) at dilution 1/60. (Original magnification: ×200)    

  
  

The RPL23A antibody is a crucial tool in studying the ribosomal protein L23a, encoded by the *RPL23A* gene in humans. As a component of the 60S large ribosomal subunit, RPL23A plays a vital role in ribosome biogenesis and protein synthesis. It is evolutionarily conserved, underscoring its fundamental role in cellular function. Research has linked RPL23A to diverse processes, including cell proliferation, differentiation, and stress responses, with dysregulation observed in cancers and genetic disorders.

Antibodies targeting RPL23A are widely used to investigate its expression, localization, and interactions. They enable techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding in the study of ribosome assembly dynamics or translational regulation. Specific RPL23A antibodies also help explore its non-ribosomal roles, such as potential involvement in p53 signaling or apoptosis.

Commercial RPL23A antibodies are typically raised in hosts like rabbits or mice using peptide antigens or recombinant proteins. Validation includes testing for specificity (e.g., knockdown controls) and cross-reactivity. Reliable antibodies are essential for accurate research, particularly when studying diseases where ribosomal dysfunction is implicated. Ongoing studies continue to clarify RPL23A's multifaceted roles, making its antibody a key reagent in molecular and cellular biology.