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MAGOHB抗体

Rabbit Polyclonal MAGOHB Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-14

湖北瑞和宁生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
MAGOHB抗体
英文名称：
Rabbit Polyclonal MAGOHB Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 5076 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
MAGOHB

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesMGN2; mago; magoh
WB Predicted band size17 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human MAGOHB
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human prostate tissue, Jurkat cell, Hela and HL-60 cell lysates, Primary antibody: P09827(MAGOHB Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09827(MAGOHB Antibody) at dilution 1/70. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09827(MAGOHB Antibody) at dilution 1/70. (Original magnification: ×200)    


           

参考文献

以下是关于MAGOHB抗体的3篇参考文献，按文献名称、作者和摘要内容概括整理：

1. **文献名称**：*MAGOHB promotes glioblastoma progression by stabilizing EJC component expression*

**作者**：Li X, et al.

**摘要**：研究揭示了MAGOHB通过稳定外显子连接复合物(EJC)成员RBM8A的表达，促进胶质母细胞瘤细胞增殖和侵袭。研究使用MAGOHB抗体进行免疫沉淀和Western blot验证其相互作用。

2. **文献名称**：*Antibody-based profiling of EJC core proteins in developmental disorders*

**作者**：Park S, et al.

**摘要**：通过MAGOHB特异性抗体分析发现，EJC复合物核心蛋白(包括MAGOHB)的异常表达与神经发育障碍相关，提示其在mRNA剪接质量控制中的关键作用。

3. **文献名称**：*MAGOHB knockdown impairs ovarian cancer metastasis via alternative splicing dysregulation*

**作者**：Zhang Y, et al.

**摘要**：利用MAGOHB抗体验证其在卵巢癌细胞中的表达，研究表明抑制MAGOHB可通过扰乱剪接因子招募，抑制肿瘤转移相关基因的可变剪接，从而抑制侵袭表型。

注：以上文献为模拟示例，实际研究中建议通过PubMed或Web of Science以"MAGOHB antibody"为关键词检索最新文献。

       

背景信息

The MAGOHB antibody is a tool used to detect MAGOHB, a protein encoded by the *MAGOHB* gene, which belongs to the Mago-Nashi homolog family. MAGOHB plays a critical role in the exon junction complex (EJC), a multiprotein assembly involved in mRNA splicing, export, surveillance, and translation. The EJC is deposited onto spliced mRNAs and coordinates downstream processes, including nonsense-mediated decay (NMD), which degulates faulty transcripts. MAGOHB shares structural and functional similarities with its paralog MAGOH, both forming heterodimers with proteins like RBM8A (Y14) within the EJC. However, MAGOHB exhibits distinct expression patterns and potential regulatory roles in specific tissues or developmental stages.

Research using MAGOHB antibodies has highlighted its importance in cellular homeostasis and disease. Studies suggest MAGOHB dysregulation may contribute to cancer progression, neurological disorders, or developmental defects, possibly due to disrupted mRNA processing or NMD. Antibodies against MAGOHB enable detection via techniques like Western blotting, immunofluorescence, or immunohistochemistry, aiding in exploring its localization, expression levels, and interactions in biological systems. These tools are vital for elucidating MAGOHB's role in RNA metabolism and its implications in pathological conditions, offering potential as a biomarker or therapeutic target.

       
MAGOHB抗体;MAGOHB;MAGOHB Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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