PDRG1抗体

The PDRG1 (p53 and DNA damage-regulated gene 1) antibody is a tool used to study the PDRG1 protein, encoded by the PDRG1 gene located on human chromosome 20q11.22. Initially identified as a p53-inducible gene under DNA damage conditions, PDRG1 is implicated in cellular stress responses, though its precise biological functions remain under investigation. Studies suggest it may play roles in regulating cell proliferation, apoptosis, and the cell cycle, with potential involvement in cancer progression. PDRG1 overexpression has been observed in various malignancies, including hepatocellular carcinoma, bladder cancer, and gliomas, correlating with poor prognosis. The antibody is widely utilized in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to detect PDRG1 expression levels in tissues or cell lines. Researchers employ it to explore PDRG1's interaction networks, post-translational modifications, and its relationship with tumorigenesis pathways, such as p53 signaling. However, discrepancies in reported expression patterns across studies highlight the need for antibody validation to ensure specificity. Recent work also investigates PDRG1's potential as a therapeutic target or diagnostic biomarker, driving demand for reliable detection tools. Its dual role in stress response and cancer biology makes the PDRG1 antibody a key reagent in both basic research and translational oncology studies.