TIMM8A抗体

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09802(TIMM8A Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The TIMM8A antibody is a tool used to detect TIMM8A (Translocase of Inner Mitochondrial Membrane 8 Homolog A), a protein critical for mitochondrial function. TIMM8A, also known as DDP1. is part of the mitochondrial TIM8-TIM13 complex, which facilitates the import and assembly of membrane proteins, particularly in the inner mitochondrial membrane. This protein plays a role in the transport of hydrophobic substrates like TIM22 complex components, essential for maintaining mitochondrial membrane potential and energy production.

Mutations in the TIMM8A gene are linked to Mohr-Tranebjaerg syndrome, an X-linked recessive disorder characterized by neurodegeneration, sensorineural hearing loss, and dystonia. Research using TIMM8A antibodies has helped elucidate its expression patterns, subcellular localization, and interaction partners, aiding in understanding mitochondrial dysfunction in disease contexts. These antibodies are widely employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study TIMM8A's role in cellular health, neurodegeneration, and metabolic disorders. Recent studies also explore its potential involvement in cancer and aging, highlighting its broader biological significance.