GPRASP2抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09800(GPRASP2 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The GPRASP2 (G Protein-Coupled Receptor Associated Sorting Protein 2) antibody is a tool used to study the function and expression of GPRASP2. a protein involved in the regulation of G protein-coupled receptor (GPCR) trafficking and degradation. GPRASP2 belongs to the GPRASP family, which plays a critical role in sorting GPCRs to lysosomes, thereby modulating receptor signaling and homeostasis. This protein is particularly implicated in the desensitization and internalization of certain GPCRs, including dopamine and opioid receptors, influencing processes like neurotransmitter signaling and cellular response pathways.

Antibodies targeting GPRASP2 enable researchers to investigate its expression patterns, subcellular localization, and interactions with GPCRs or other regulatory proteins. These antibodies are commonly utilized in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation. Studies involving GPRASP2 antibodies have shed light on its potential roles in neurological disorders, addiction mechanisms, and cancer, where GPCR dysregulation is often observed.

The development and validation of GPRASP2 antibodies typically involve specificity tests using knockout cell lines or tissues to ensure minimal cross-reactivity with related family members like GPRASP1. As GPCR signaling pathways are therapeutic targets for numerous diseases, understanding GPRASP2's function through antibody-based research contributes to unraveling its pathophysiological relevance and potential as a drug target. Commercial availability of these antibodies facilitates broader exploration in both basic and translational research contexts.