THOP1抗体

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebrum tissue and Human fetal brain tissue lysates, Primary antibody: P09790(THOP1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09790(THOP1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The THOP1 (Thimet Oligopeptidase 1) antibody is a tool used to detect and study the THOP1 protein, a zinc-dependent metalloprotease belonging to the M3 peptidase family. THOP1. also known as endopeptidase 24.15. is involved in peptide metabolism, particularly in cleaving small bioactive peptides (e.g., neuropeptides, hormones) within cells. It localizes to the cytoplasm and nucleus, playing roles in regulating peptide signaling, antigen presentation, and protein degradation pathways. Dysregulation of THOP1 has been linked to neurological disorders, cancer, and immune dysfunction.

The antibody enables researchers to investigate THOP1's expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It is critical for elucidating THOP1's physiological functions, such as its proposed involvement in Alzheimer’s disease via amyloid-beta peptide processing, or its dual role in cancer progression as both a tumor suppressor and promoter. Commercial THOP1 antibodies are typically raised against specific epitopes (e.g., human THOP1 amino acid sequences) and validated for cross-reactivity in model organisms. Ongoing research focuses on its therapeutic potential as a drug target or biomarker.