AOAH抗体

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HL-60 cell lysate, Primary antibody: P09775(AOAH Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09775(AOAH Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

AOAH (acyloxyacyl hydrolase) is an enzyme primarily produced by macrophages and neutrophils, playing a critical role in modulating innate immune responses. It specifically deacylates bacterial lipopolysaccharides (LPS), a key component of Gram-negative bacterial outer membranes. By cleaving secondary acyl chains from the lipid A moiety of LPS, AOAH converts highly inflammatory endotoxins into less stimulatory forms, thereby limiting excessive immune activation and preventing tissue damage during infections.

AOAH antibodies are tools used to study this enzyme’s expression, localization, and function. They enable researchers to detect AOAH in immune cells, assess its regulation under inflammatory conditions, and explore its role in sepsis, autoimmune diseases, or metabolic disorders. AOAH-deficient mice exhibit prolonged LPS-induced inflammation, highlighting its importance in immune homeostasis. Antibodies targeting AOAH also aid in investigating therapeutic strategies, such as enhancing endotoxin detoxification or modulating inflammatory pathways. Clinically, AOAH activity or its suppression has been linked to chronic inflammatory conditions, making related antibodies valuable for diagnostic or biomarker research. Their applications extend to understanding host-microbe interactions, as AOAH’s function influences both pathogen clearance and resolution of inflammation.