COG4抗体

The COG4 antibody is a research tool targeting the COG4 protein, a critical subunit of the Conserved Oligomeric Golgi (COG) complex. The COG complex, composed of eight subunits (COG1-8), regulates vesicle trafficking and glycosylation within the Golgi apparatus. COG4. part of the COG1-4 subcomplex (lobe B), interacts with SNARE proteins and Rab GTPases to maintain Golgi structure and function. Mutations in COG4 are linked to congenital disorders of glycosylation (CDGs), particularly COG4-CDG (formerly CDG-IIj), characterized by developmental delays, hypotonia, and impaired protein glycosylation. COG4 antibodies enable detection and localization of COG4 in cells, aiding studies on Golgi dynamics, vesicular transport, and disease mechanisms. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate COG4's role in cellular homeostasis and pathology. Their development has advanced understanding of COG complex dysfunction in neurological disorders and metabolic diseases, highlighting COG4's essentiality in maintaining Golgi integrity and proper protein trafficking.