XPNPEP3抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: PC-3 and 293T cell lysates, Primary antibody: P09764(XPNPEP3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P09764(XPNPEP3 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09764(XPNPEP3 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

XPNPEP3 (X-prolyl aminopeptidase 3) is a mitochondrial enzyme belonging to the M24B metallopeptidase family. It catalyzes the hydrolysis of N-terminal Xaa-Pro bonds in peptides, regulating bioactive molecules involved in cellular processes such as inflammation, cell cycle progression, and mitochondrial function. The gene encoding XPNPEP3 is located on chromosome 22q13.2. and mutations in this gene have been linked to autosomal recessive disorders, including a rare form of nephronophthisis-like cystic kidney disease and mitochondrial encephalomyopathy.

XPNPEP3 antibodies are essential tools for studying the enzyme’s expression, localization, and functional roles. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect XPNPEP3 in tissues and cultured cells. Research has highlighted its significance in mitochondrial metabolism, particularly in maintaining respiratory chain integrity and energy production. Dysregulation of XPNPEP3 is also implicated in pathological conditions, such as renal tubulopathies and neurodegenerative diseases.

Antibodies targeting XPNPEP3 aid in elucidating disease mechanisms and validating protein interactions, supporting translational studies for biomarker discovery or therapeutic targeting. Specificity and validation data (e.g., knockout controls) are critical for ensuring reliable experimental outcomes. Ongoing research continues to explore its broader roles in cellular homeostasis and disease progression.