BPIFB1抗体

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09754(BPIFB1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The BPIFB1 (BPI fold-containing family B member 1) antibody is a tool used to detect the BPIFB1 protein, which belongs to the bactericidal/permeability-increasing protein (BPI) family. BPIFB1. also known as LPLUNC1. is encoded by the *BPIFB1* gene located on chromosome 20q11.21. This protein is primarily expressed in mucosal epithelial tissues, including the respiratory tract, oral cavity, and nasopharynx, suggesting a role in innate immunity and host defense. Structurally, it contains a characteristic BPI fold, which facilitates lipid-binding activities, potentially targeting bacterial lipopolysaccharides (LPS) to neutralize pathogens or modulate inflammatory responses.

Research highlights BPIFB1's involvement in chronic inflammatory diseases, such as sinusitis and cystic fibrosis, where its expression is often dysregulated. It may also play a dual role in carcinogenesis, acting as a tumor suppressor in certain cancers (e.g., nasopharyngeal carcinoma) while promoting cell survival in others. The BPIFB1 antibody is widely utilized in techniques like immunohistochemistry (IHC), Western blotting (WB), and immunofluorescence (IF) to study its localization, expression patterns, and interactions in disease models. Recent studies explore its potential as a diagnostic or prognostic biomarker, though its precise molecular mechanisms remain under investigation. Commercial antibodies vary in specificity, requiring validation via knockout controls or peptide-blocking assays to ensure reliability.