RRP1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Jurkat, 293T, Hela and HEPG2 cell lysates, Primary antibody: P09738(RRP1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09738(RRP1 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P09738(RRP1 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The RRP1 (Ribosomal RNA Processing 1) antibody is a tool used to study the RRP1 protein, a key component involved in ribosome biogenesis and RNA processing. RRP1. also known as Exosome Component 3 (EXOSC3), is part of the exosome complex, a multi-subunit machinery critical for processing and degrading various RNA species, including ribosomal RNA (rRNA), small nuclear RNA (snRNA), and messenger RNA (mRNA). It plays a vital role in RNA quality control, maturation, and turnover, ensuring proper cellular function. Dysregulation of RRP1 has been linked to developmental disorders, neurodegenerative diseases, and cancers.

RRP1 antibodies are widely employed in molecular biology research to investigate the protein's expression, localization, and interactions. They are commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess RRP1 levels in different tissues or disease models. Such studies help elucidate its role in cellular processes like cell cycle progression, stress responses, and tumorigenesis. Commercial RRP1 antibodies are typically generated in rabbits or mice, targeting specific epitopes of the human RRP1 protein. Validation includes testing for specificity via knockout/knockdown controls. Researchers rely on these antibodies to explore RRP1's functional mechanisms and its potential as a biomarker or therapeutic target in diseases associated with RNA dysregulation.