SEPTIN10抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue lysate, Primary antibody: P09734(SEPTIN10 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 80 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09734(SEPTIN10 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09734(SEPTIN10 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

The SEPTIN10 antibody is a research tool designed to detect and study the SEPTIN10 protein, a member of the septin family involved in diverse cellular processes. Septins are GTP-binding proteins that form filamentous structures, contributing to cytoskeletal organization, cell division, membrane remodeling, and vesicle trafficking. SEPTIN10. specifically, plays roles in spermatogenesis, neuronal development, and cilia function, with emerging links to male infertility, neurodevelopmental disorders, and cancer.

Antibodies targeting SEPTIN10 are typically generated in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate SEPTIN10's expression patterns, subcellular localization, and interactions in normal and diseased tissues. Commercial SEPTIN10 antibodies are available from suppliers like Abcam, Sigma-Aldrich, and Novus Biologicals, often validated for specificity across human, mouse, or rat models.

Current research leverages these antibodies to explore SEPTIN10's functional aberrations, such as disrupted sperm tail formation or defective cilia in pathological conditions. However, challenges remain, including cross-reactivity with other septin isoforms and variable validation standards. Proper controls (e.g., knockout validation) are critical to ensure antibody reliability. Ongoing studies aim to clarify SEPTIN10's mechanistic roles and therapeutic potential, highlighting its importance in cellular dynamics and disease pathways.