TUBG2抗体

The TUBG2 antibody targets gamma-tubulin 2 (TUBG2), a member of the γ-tubulin family critical for microtubule nucleation and mitotic spindle formation. γ-tubulins are core components of the γ-tubulin ring complex (γ-TuRC), which serves as a template for microtubule assembly in eukaryotic cells. While TUBG1 (gamma-tubulin 1) is ubiquitously expressed, TUBG2 shows more restricted expression, primarily in the brain and reproductive tissues. Both isoforms contribute to centrosome function, ensuring proper cell division and microtubule organization. TUBG2 antibodies are essential tools in studying these processes, enabling detection of protein localization via immunofluorescence, quantification by Western blot, or analysis of expression patterns in developmental and disease contexts. Research using TUBG2 antibodies has explored its role in neurodevelopment, cancer (e.g., chromosomal instability in tumors), and cilia-related disorders. Specific antibodies are validated for cross-reactivity, isoform specificity (distinguishing TUBG2 from TUBG1), and compatibility with experimental models, including human, mouse, and rat tissues. Dysregulation of TUBG2 has been implicated in microcephaly and other mitotic defects, highlighting its importance in cellular and organismal homeostasis.