NCAPG抗体

The NCAPG antibody is a tool used to detect NCAPG (Non-SMC Condensin I Complex Subunit G), a protein involved in chromosome organization and segregation during cell division. NCAPG is a key component of the condensin I complex, which plays a critical role in condensing chromatin and ensuring proper sister chromatid separation in mitosis and meiosis. Dysregulation of NCAPG has been linked to genomic instability, a hallmark of cancer, and its overexpression is observed in various malignancies, including hepatocellular carcinoma, prostate cancer, and lung adenocarcinoma. Researchers utilize NCAPG antibodies in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study its expression patterns, subcellular localization, and association with tumor progression or therapeutic resistance. These antibodies also aid in exploring NCAPG's interactions with other condensin complex subunits and its role in regulating cell cycle checkpoints. Recent studies suggest NCAPG as a potential biomarker for cancer prognosis and a target for anticancer strategies, driving interest in developing high-specificity antibodies for diagnostic and research applications.