BZW2抗体

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     The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09711(BZW2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The BZW2 (Basic Leucine Zipper and W2 Domains 2) antibody is a tool used to study the BZW2 protein, encoded by the *BZW2* gene. BZW2. also known as HSPC240. is a member of the bZIP family of transcription factors and is implicated in regulating cellular stress responses, protein synthesis, and cell proliferation. It interacts with the integrated stress response (ISR) pathway, particularly under conditions like nutrient deprivation or endoplasmic reticulum (ER) stress, where it modulates the activity of eukaryotic initiation factors (eIFs) to control mRNA translation.

Research highlights BZW2's role in cancer biology. Overexpression of BZW2 is observed in several cancers, including breast, liver, and glioblastoma, where it promotes tumor progression, metastasis, and therapy resistance by enhancing cell survival and adaptation to stress. The BZW2 antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression levels, subcellular localization, and interactions in both normal and pathological tissues.

Studies utilizing this antibody have contributed to understanding BZW2's regulatory mechanisms, such as its crosstalk with mTOR and integrin signaling pathways. Its development and validation support ongoing investigations into BZW2 as a potential diagnostic marker or therapeutic target in stress-related diseases and oncology.