NOLC1抗体

The NOLC1 (Nucleolar and Coiled-Coil Phosphoprotein 1) antibody is a tool used to detect the NOLC1 protein, a nucleolar phosphoprotein critical for ribosome biogenesis and nucleolar organization. NOLC1. also known as Nucleostemin or NOPP140. interacts with RNA polymerase I and other nucleolar proteins, facilitating rRNA processing and ribosome assembly. It plays roles in cell cycle regulation, stress responses, and maintaining nucleolar structure. Dysregulation of NOLC1 has been linked to cancers, including hepatocellular carcinoma and glioblastoma, where its overexpression correlates with tumor progression. The antibody is widely employed in techniques like Western blotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to study NOLC1's expression, localization, and interactions in cellular models or pathological tissues. Researchers also use it to explore NOLC1's phosphorylation dynamics, which modulate its function during mitosis or under DNA damage. As a nucleolar marker, NOLC1 antibodies help investigate nucleolar stress in aging, neurodegenerative diseases, or chemotherapeutic responses. Commercial NOLC1 antibodies are typically raised against specific epitopes, often validated for cross-reactivity in human, mouse, or rat samples. Its utility spans basic nucleolar biology and translational studies targeting ribosome-related pathologies.