OLA1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A375 cell lysate, Primary antibody: P09699(OLA1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P09699(OLA1 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09699(OLA1 Antibody) at dilution 1/55. (Original magnification: ×200)    

  
  

The OLA1 (Obg-like ATPase 1) antibody is a tool used to study the OLA1 protein, a conserved member of the YchF subfamily of GTPases involved in cellular stress response and translational regulation. OLA1. encoded by the *OLA1* gene in humans, plays dual roles in ATP/GTP hydrolysis and interacts with critical cellular components like stress granules, ribosomes, and translation factors. It modulates protein synthesis under stress conditions, influences cell proliferation, apoptosis, and oxidative stress adaptation, and has been implicated in diseases such as cancer and neurodegenerative disorders.

Antibodies targeting OLA1 enable researchers to investigate its expression, localization, and function through techniques like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies are essential for identifying OLA1's role in pathways like mTOR and AMPK signaling, as well as its potential as a biomarker in tumors, where its expression often correlates with prognosis. Available as monoclonal or polyclonal variants, OLA1 antibodies are validated for specificity across human and model organisms, aiding mechanistic studies in cellular stress responses and disease pathogenesis. Their applications span basic research, drug discovery, and diagnostic development.