HENMT1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HEPG2 cell lysate, Primary antibody: P09698(HENMT1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human kidney cancer tissue using P09698(HENMT1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09698(HENMT1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The HENMT1 (Hen Methyltransferase 1) antibody is a tool used to study the HENMT1 protein, a conserved RNA methyltransferase critical for piRNA (PIWI-interacting RNA) biogenesis. HENMT1 catalyzes the 2′-O-methylation of the 3′ termini of piRNAs, a post-transcriptional modification essential for their stability and function in silencing transposable elements and maintaining genome integrity, particularly in germline cells and during early development.

HENMT1 is a key component of the piRNA pathway, and its dysfunction has been linked to infertility, genomic instability, and developmental defects in model organisms. The antibody enables detection and localization of HENMT1 in various experimental settings, such as Western blotting, immunofluorescence, and immunohistochemistry, aiding research on piRNA-mediated gene regulation, epigenetic mechanisms, and reproductive biology.

Developed in hosts like rabbits or mice, HENMT1 antibodies are often validated using knockout controls or enzymatic assays to confirm specificity. Their application spans studies in germ cell development, transposon suppression, and diseases associated with piRNA pathway dysregulation. As piRNA research expands into cancer, neurodegeneration, and aging, HENMT1 antibodies remain vital for elucidating its role in these processes.