ACTC1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue lysate, Primary antibody: P09686(ACTC1 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 second    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09686(ACTC1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The ACTC1 antibody is a research tool targeting the alpha-cardiac actin protein, encoded by the ACTC1 gene. This gene is part of the actin family, which comprises essential cytoskeletal proteins involved in cell structure, motility, and muscle contraction. ACTC1 is predominantly expressed in cardiac muscle, where it plays a critical role in sarcomere organization and contractile function. It constitutes a major component of the thin filaments in cardiomyocytes, interacting with myosin to enable heart muscle contraction.

ACTC1 antibodies are widely used in cardiovascular research to study protein expression, localization, and regulatory mechanisms in both healthy and diseased tissues. They are applied in techniques such as immunohistochemistry, Western blotting, and immunofluorescence to investigate conditions like hypertrophic cardiomyopathy, dilated cardiomyopathy, and congenital heart defects. Mutations in ACTC1 have been linked to these cardiac disorders, making the antibody valuable for elucidating disease pathways.

Additionally, ACTC1 antibodies occasionally aid in studying skeletal muscle biology, as low levels of alpha-cardiac actin may be present in skeletal muscle. Their specificity is rigorously validated to avoid cross-reactivity with other actin isoforms (e.g., alpha-skeletal or cytoplasmic actins). As cardiac diseases remain a leading cause of mortality, ACTC1 antibodies serve as key tools for advancing diagnostic and therapeutic strategies targeting actin-related pathologies.