TADA3抗体

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09683(TADA3 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The TADA3 (Transcriptional Adaptor 3) antibody is a tool used to detect the TADA3 protein, a critical component of the human ADA2A-containing histone acetyltransferase (HAT) complex. TADA3. also known as ADA3. plays a pivotal role in chromatin remodeling and transcriptional regulation by interacting with p300/CBP-associated factor (PCAF) and p300/CBP complexes. It facilitates histone acetylation, modifying chromatin structure to enable access for transcriptional machinery. TADA3 is essential for cell cycle progression, DNA repair, and apoptosis, with its dysfunction linked to cancer progression and developmental disorders.

Studies highlight TADA3's interaction with tumor suppressor p53. enhancing its stability and transcriptional activity, thereby influencing cell fate decisions under stress. Its involvement in oncogenic pathways, such as HER2 signaling in breast cancer, underscores its dual role as both a potential oncogene and tumor suppressor, depending on cellular context. TADA3 antibodies are widely utilized in research to explore these mechanisms via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercially available TADA3 antibodies are typically validated for specificity and sensitivity across species, aiding in studies of protein expression patterns in normal tissues versus malignancies. Recent work also implicates TADA3 in metabolic reprogramming and chemotherapy resistance, making it a target for therapeutic exploration. Its conserved domains and post-translational modifications further drive interest in structural and functional analyses.